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节律与同步-神经科学百科全书-14 版权信息
- ISBN:9787030280763
- 条形码:9787030280763 ; 978-7-03-028076-3
- 装帧:暂无
- 册数:暂无
- 重量:暂无
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节律与同步-神经科学百科全书-14 本书特色
《神经科学百科全书14:节律与同步(导读版)》是由科学出版社出版的。
节律与同步-神经科学百科全书-14 目录
节律与同步-神经科学百科全书-14 节选
《神经科学百科全书14:节律与同步(导读版)》原书篇幅巨大,为所有神经科学百科全书之首。由来自世界各地的2400多位专家撰稿人合力打造,覆盖了神经科学全部主要领域。每个词条在收入书中之前均经过顾问委员会的同行评议,词条中均含有词汇表、引言、参考文献和丰富的交叉参考内容。主编为著名神经科学家、美国神经科学学会前主席LarryR.Squire。内容平易,本科生即可读懂。深度和广度独一无二,足可满足专家学者的需要。导读版精选原书中的部分主题,按内容重新编排,更适合国内读者购买和阅读。
节律与同步-神经科学百科全书-14 相关资料
插图:The alternation of light and dark is the most reliable timing cue on our planet, and therefore it is not surprising that the retina has evolved a precise timing mechanism that allows it to anticipate and then to adapt to the more than 1 million-fold change in light intensity during a 24 h period. The retina was the first extra-SCN oscillator to be discovered in mammals. Several studies have now demonstrated that many of the physiological, cellular, and molecular rhythms that are present within the retina are under the control of a circadian clock, or more likely a series of circadian clocks that are present within this tissue (Figure 1). For example, the disk shedding that occurs in the rod photoreceptors is under circadian control. Shedding persists in animals with SCN lesions or a transected optic nerve, indicating its independence from the central circadian pacemaker. Additional studies have reported that sensitivity to light-induced photoreceptor damage is modulated by the circadian clock via a cyclic adenosine monophosphate (cAMP)-dependent pathway. Other important retinal functions, such as visual sensitivity, are also under circadian control. Although results from these studies suggested that retinal physiology was regulated by a circadian clock, they were not sufficient to conclude that an independent circadian pacemaker was located within the retinal tissue. The definitive demonstration of the presence of an autonomous retinal clock in mammals was achieved a few years ago when it was shown that a circadian rhythm of melatonin release persisted in mammalian retinas maintained in culture. In light/ dark cycles, melatonin levels were high during the night and low during the day. In constant darkness, the circadian rhythm of melatonin release free-ran, exhibiting a period close to 24 h. The circadian rhythm of melatonin release in the retina can be entrained by light in vitro and is temperature compensated. Such results demonstrated that the retina can be considered a bona fide circadian pacemaker, since it satisfies the three fundamental properties (i.e., freerunning, entrainment, and temperature compensation) that describe a circadian rhythm.
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